September 30, 2020, 08:14:29 pm

It's in the Works

Started by JohnDB, August 10, 2020, 11:25:35 am

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JohnDB

The good news we have been waiting for is on its way...

A cure for Covid-19.
https://www.businesswire.com/news/home/20200721005042/en/Selva-Therapeutics-Announces-3-Million-Series-Financing

Supplanter (my wife) told me about how Vanderbilt University had done some of the research for this company on this drug.

It's in clinical trials.
It works.

Normalcy is on the horizon.
I wanna die like grandpa, peacefully and in his sleep. Not like the passengers in his car...they were all screaming and panicking.

Bryan

Now the question becomes is it wise to get the vaccine?  A good portion would say no
All glory to him who loves us and has freed us from our sins by shedding his blood for us.  He has made us a Kingdom of priests for God his Father. All glory and power to him forever and ever! Amen.

JohnDB

Quote from: Bryan on August 11, 2020, 07:10:24 amNow the question becomes is it wise to get the vaccine?  A good portion would say no
Historically vaccines for Corona class viruses don't work and usually make the recipients more sick when they contract the virus they are supposed to protect against.

So...
No...I'm not going to take that double shot and subsequent ones.

(It's a series of painful injections)
I wanna die like grandpa, peacefully and in his sleep. Not like the passengers in his car...they were all screaming and panicking.

flaglady

Quote from: JohnDB on August 10, 2020, 11:25:35 amIt's in clinical trials.
It works.

Respectfully, I would dispute those two phrases. Being in clinical trials is not a precursor to the success or failure of a drug or vaccine.  In days way back when Jenner developed the small pox vaccine, life was a lot simpler. Such is not the case now. Rules and protocols multiply and for good reasons. Some of the 'vaccines' that have been developed thus far are proving themselves to be either ineffective or harmful. I'm not saying this will be the case with this new treatment. Perhaps it will be fantastically successful but then again, perhaps it won't. So all I am saying is, be cautious and be wary and watchful. This vaccine involves mega-bucks and where there is a lot of money, manufacturers are not to be trusted.

JohnDB

Oh I agree...
The vaccines they are developing are scarier to me than an antiviral.
A vaccine is designed for a long lasting impression on your body...the effects can last decades. And if it's a bad effect?

An antiviral is very different. Short term effect and impression.

This one was made from an existing medicine's model.
It's just a variation of a theme.

Only way I can describe it is that many of your antibiotics are variations of penicillin. This antiviral is similar to an existing antiviral but is a lot more effective and less expensive.

Min/max and duration dosing is primarily what they are looking for.

It's coming....I'm hoping for a very merry Christmas.
I wanna die like grandpa, peacefully and in his sleep. Not like the passengers in his car...they were all screaming and panicking.

flaglady

Quote from: JohnDB on August 13, 2020, 10:45:11 amThis one was made from an existing medicine's model.
It's just a variation of a theme.
Most 'new' drugs are but it doesn't make them any safer.

I remember engaging with my mother's GP some years ago because he had covertly got her to sign up as a participant in one of his research studies. She didn't want it and he wouldn't answer her questions in plain English - she was 80 at the time and not particularly knowledgeable about things like this so she rang me for advice. It also appeared that he had had her sign the bottom of a page while he covered up the rest.

So I went to see her GP and was horrified to see in his office shelves of files for such studies. Of course, I knew he was raking in the money for these 'studies'. Shameful. It seemed he had tried to convince my mother that she needed this new drug because her condition (slightly raised blood pressure) had worsened. He tried hard to convince me that it was 'only' because the company had changed one component, protocol required the study was done again. But what he didn't know is that I was a senior administrative nurse. He backed down and took her off the study.

I'm sure not all doctors are so unscrupulous but I bet an awful lot of them are!

JohnDB

Clinical trials...

No one is going to take this antiviral unless they know...

Then there's at least two screenings by those giving out the medicine and a double screening by the drug company.

These double screening are for trying to ensure the patient can tolerate the medicine...if anything these days they skew the numbers towards approval...but not by two separate entities.

Then there's the blizzard of paperwork and monitoring.

Then there's the whole double blind thing... nobody really knows who is or is not getting the meds.
I wanna die like grandpa, peacefully and in his sleep. Not like the passengers in his car...they were all screaming and panicking.

flaglady


Pete

Here's an image I just posted on Facebook today. This is a dot map showing the impact of COVID-19 on the United States in the context of the entire population. Each square represents 10,000 people. Green squares represent people who tested negative. Blue squares represent people who tested positive but have since recovered. Yellow squares represent active infections. Red squares represent people who have died.

You cannot see attachments on this board.

:afro:
"There is no charge for awesomeness -- or attractiveness."

JohnDB

Quote from: Pete on August 18, 2020, 06:29:21 pmHere's an image I just posted on Facebook today. This is a dot map showing the impact of COVID-19 on the United States in the context of the entire population. Each square represents 10,000 people. Green squares represent people who tested negative. Blue squares represent people who tested positive but have since recovered. Yellow squares represent active infections. Red squares represent people who have died.

You cannot see attachments on this board.

:afro:

Unfortunately I live in the grey section right next to the yellow and red squares.
The green is in my neighborhood too. Same as the Blue.

Construction workers are a hot group...they have had whole jobs with 97% positive tests. Of course they send everyone home and get new temps to replace them.
We are disposable.

So most temps go to another agency and go right back out to work to infect another jobsite.

Where I think that I could get over the virus I'm not sure if my wonderful wife would...she is not replaceable. One of a kind and very unique. She probably would survive but be one of those who got damaged kidneys, heart, lungs, or liver.

Soooo....
I'm going to be waiting for the drugs that fight this thing.
I wanna die like grandpa, peacefully and in his sleep. Not like the passengers in his car...they were all screaming and panicking.

JohnDB

Either way the drug company is in clinical trials.

The third quarter ends in September...
Then comes stage 2 trials which is when the proper size dosing comes along and begins to treat people...they are looking for different things at all stages of the trials.

Stage 3 is some group's lucky day.

It's when a region gets widespread use. It could be a state, a small nation, or something else where thousands of people are exposed to the new drug.
I wanna die like grandpa, peacefully and in his sleep. Not like the passengers in his car...they were all screaming and panicking.

Pete

August 24, 2020, 09:21:47 am #11 Last Edit: August 24, 2020, 09:36:23 am by Pete
Here's another study about the misperceptions of risk in COVID-19. Some interesting data points from the article;

1. On average, Americans believe that people aged 55 and older account for just over half of total COVID-19 deaths; the actual figure is 92%.

2. Americans believe that people aged 44 and younger account for about 30% of total deaths; the actual figure is 2.7%.

3. Americans overestimate the risk of death from COVID-19 for people aged 24 and younger
by a factor of 50; and they think the risk for people aged 65 and older is half of what it actually is (40% vs 80%).


If you're a facts and figures kind of person and geek out on data like I do, I highly suggest reading the whole thing. While there is absolutely a risk associated with COVID-19, I believe this study demonstrates that Americans have a gross and disproportionate level of concern vs. reality.

This is not to say I don't think they should be working on treatments and/or vaccines.  Just to say that data doesn't support the level of hysteria and concern we've been told is necessary.

https://www.franklintempleton.com/investor/article?contentPath=html/ftthinks/en-us-retail/cio-views/on-my-mind-they-blinded-us-from-science.html

O0
"There is no charge for awesomeness -- or attractiveness."

JohnDB

Quote from: Pete on August 24, 2020, 09:21:47 amHere's another study about the misperceptions of risk in COVID-19. Some interesting data points from the article;

1. On average, Americans believe that people aged 55 and older account for just over half of total COVID-19 deaths; the actual figure is 92%.

2. Americans believe that people aged 44 and younger account for about 30% of total deaths; the actual figure is 2.7%.

3. Americans overestimate the risk of death from COVID-19 for people aged 24 and younger
by a factor of 50; and they think the risk for people aged 65 and older is half of what it actually is (40% vs 80%).


If you're a facts and figures kind of person and geek out on data like I do, I highly suggest reading the whole thing. While there is absolutely a risk associated with COVID-19, I believe this study demonstrates that Americans have a gross and disproportionate level of concern vs. reality.

This is not to say I don't think they should be working on treatments and/or vaccines.  Just to say that data doesn't support the level of hysteria and concern we've been told is necessary.

https://www.franklintempleton.com/investor/article?contentPath=html/ftthinks/en-us-retail/cio-views/on-my-mind-they-blinded-us-from-science.html

O0

I agree with a lot of things that the article talks about.
And it furthers my POV.

The chances of dying from this virus is fairly low for most people.
I'm one of those in the 50+ range with "comorbidities".
Supplanter (wife) has her physical ailments too but is much younger than me.

I'm not concerned that I will die... neither is she. That never has been our real concern all along.

Our main concern is the sepsis reaction that causes all the damage from getting this virus.

There's a huge group of people who have "recovered" but now have kidney, liver, heart, or lung damage from the sepsis reaction to this virus...they may not have needed to even go to the hospital...but they still feel dragging around for months...

That's our biggest fear. Fairly certain that I'm tougher than a bug...don't mind being sick either.

I do mind never getting my wind back...or having heart issues when I never had them before. Kidneys are hard to come by too...mine are already on their last leggs from all the caffeine.

That's the real reason for pause.

There's a bunch of hubaloo over a three weeks long fishing charter boat from Seattle that left with one or more guys sick...there was only three guys that came back who weren't sick because they had it before.

Everyone else had a case of it and one guy had to be hospitalized...there was 120+ people on board the charter vessel.

High high contagion rate.
One guy in the hospital who I'm sure will live out of over 120 cases.
Of course I expect to live if I get this thing...might not, but hey...can't threaten me with a good time. But being more of an invalid than I already am? Arthritis sucks, having even more issues breathing than allergies? Kidney issues?
No thanks!
I wanna die like grandpa, peacefully and in his sleep. Not like the passengers in his car...they were all screaming and panicking.